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Table 5 Distribution of SNPs and types of mutations in immune and antioxidant genes in healthy and pneumonia-affected sheep

From: Single nucleotide polymorphisms, gene expression and evaluation of immunological, antioxidant, and pathological parameters associated with bacterial pneumonia in Barki sheep

Gene

SNPs

Healthy

Pneumonia

Total

Type of mutation

Amino acid number and type

IL-1α

T111C

21

-

21/100

Synonymous

37 D

A122G

32

-

32/100

Non-synonymous

41 E to G

T285C

-

26

26/100

Synonymous

95 D

IL-1β

C56T

-

17

17/100

Non-synonymous

19 S to L

IL-6

C66T

-

34

34/100

Synonymous

22 H

TNF-α

C174T

22

-

22/100

Synonymous

58 A

C278T

-

28

28/100

Non-synonymous

93 S to L

T330C

-

41

41/100

Synonymous

110 S

IL-10

G87C

38

-

38/100

Synonymous

29 P

C137G

-

25

25/100

Non-synonymous

46 P to R

G174A

-

36

36/100

Synonymous

58 Q

T374C

33

-

33/100

Non-synonymous

125 M to T

G404A

-

29

29/100

Non-synonymous

135 R to H

LFA-1

C85T

-

14

14/100

Non-synonymous

29 R to C

A142G

43

-

43/100

Non-synonymous

48 S to G

G154A

35

-

35/100

Non-synonymous

52 G to S

T281C

-

24

24/100

Non-synonymous

94 L to P

CR2

C100G

37

-

37/100

Non-synonymous

34 L to V

T111C

28

-

28/100

Synonymous

37 D

T269A

34

-

34/100

Non-synonymous

90 L to M

IL-17

G72A

29

-

29/100

Synonymous

24 G

T327C

-

31

31/100

Synonymous

109 N

T360C

39

-

39/100

Synonymous

120 L

IL-13

C294A

-

36

36/100

Non-synonymous

98 H to Q

DEFB123

A56G

-

40

40/100

Non-synonymous

19 H to R

T186G

-

21

21/100

Non-synonymous

62 H to Q

SCART1

C77G

42

-

42/100

Non-synonymous

26 P to R

ICAM1

C114T

-

31

31/100

Synonymous

38 L

C232T

17

-

17/100

Non-synonymous

78 P to S

SOD1

T51C

36

-

36/100

Synonymous

17 S

C196T

-

16

16/100

Synonymous

66 L

G208T

24

-

24/100

Non-synonymous

70 D to Y

CAT

T64C

-

17

17/100

Synonymous

22 L

C158T

-

44

44/100

Non-synonymous

53 A to V

GPX1

C62G

-

32

32/100

Non-synonymous

21 P to R

C193A

13

-

13/100

Non-synonymous

65 H to N

C256G

45

-

45/100

Non-synonymous

89 R to G

C298T

33

-

33/100

Non-synonymous

100 R to C

G391C

-

25

25/100

Non-synonymous

131 E to Q

NOS

G175A

19

-

19/100

Non-synonymous

59 A to T

A244C

42

-

42/100

Non-synonymous

82 S to R

C367T

30

-

30/100

Non-synonymous

123 P to S

T457C

-

15

15/100

Non-synonymous

153 W to R

HMOX1

C33T

-

27

27/100

Synonymous

11 P

C108T

44

-

44/100

Synonymous

36 A

C352T

-

23

23/100

Non-synonymous

118 R to C

NQO1

G56T

25

-

25/100

Non-synonymous

19 R to L

G244A

17

-

17/100

Non-synonymous

82 G to R

  1. -A= Alanine; C= Cisteine; D= Aspartic acid; E= Glutamic acid; G= Glycine; H= Histidine; L= Leucine; M= Methionine; N= Asparagine; P= Proline; Q= Glutamine; R= Argnine; S= Serine; T= Threonine; V= Valine; W= Tryptophan; and Y= Tyrosine
  2. -IL-1α Interleukin 1 alpha, IL-1β Interleukin 1 beta, IL-6 Interleukin 6, TNF- α Tumor necrosis factor- alpha, IL10 Interleukin 10, LFA-1 Lymphocyte function-associated antigen 1, CR2 Complement C3d receptor 2, IL-17 Interleukin 17, IL-13 Interleukin 13, DEFB123 β-defensin, SCART1 Scavenger Receptor Family Member Expressed On T Cells 1, ICAM1 intercellular adhesion molecule 1, SOD1 Superoxide dismutase 1, CAT Catalase, GPX1 Glutathione peroxidase 1, NOS Nitric oxide synthetase, HMOX1 Heme Oxygenase 1, NQO1 NAD(P)H Quinone Dehydrogenase 1
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Irish Veterinary Journal

ISSN: 2046-0481